Abstract Given the lack of standardized guidance for follow-up of patients with neuronal ceroid lipofucsinosis-2 disease in Latin-American countries and the heterogeneity of the region, an expert panel was created with the participation of 11 pediatric neurologists from Colombia, Argentina, Brazil and Chile. The aim of the expert panel was to describe a framework for standardized follow-up in patients with neuronal ceroid lipofucsinosis-2 disease, on or off therapy, that could benefit patients and treating physicians alike. Experts made recommendations in the following areas: seizures, abnormal movements and ataxia, sleep disorders and pain, cognitive function, visual function, hearing and speech, cardiac function, quality of life, and motor function. Recommendations include the most appropriate tools for use in the Latin-American context and health care systems, and provide feasible follow-up guidance, applicable in public and private healthcare facilities. They take into consideration the availability of clinical assessment resources, tools (scales, questionnaires, paraclinical tests) and access to these tools in Latin-American countries, as well as other regional and local needs defined by the participating experts.

RESUMEN Las actividades productivas que se realizan en la cuenca del embalse de Riogrande II (Antioquia, Co- lombia) generan afectaciones ambientales negativas sobre suelo y agua. La integración de modelos hidrológicos y económicos provee una base científica para un escenario planeado de uso del territorio, que sea racional y adecuado a la actual vocación agropecuaria. Partiendo de los datos generados a partir del modelo SWAT se reformula el modelo Ecosaut para determinar el uso óptimo de suelo acorde con restricciones ambientales y sociales, encontrando que, para asegurar la sostenibilidad de la cuenca, es necesario implementar un sistema de rotación compuesto por pastos y cultivo de papa junto con una reducción de alrededor del 42 % del suelo actualmente dedicado a actividades agrícolas. JEL: Q12, Q15, Q24, Q25 CONTENIDO: Introducción; 1. Caracterización de la cuenca; 2. Metodología; 3. Resultados y discusión; 5. Conclusiones; Bibliografía.

ABSTRACT The productive activities carried out at the basin of the Riogrande II press (Antioquia, Colombia) generate negative environmental affections upon the soil and water. The integration of hydrological and economical models provides a scientific foundation for planned use of the territory that is rational and adequate for the actual agricultural vocation. Starting from the data generated by the SWAT model, the Ecossaut model is reformulated for determining the optimal use of the soil according to the social and environmental restrictions, finding out that in order to reassure the reliability of the basin is necessary an implementation of rotation system composed of grass and potato crops along with a reduction of around 42 % of the soil currently used for agricultural activities. JEL CODE: Q12, Q15, Q24, Q25 CONTENTS: Introduction; 1. Basin characterization; 2. Methodology; 3. Results and discussion; 5. Conclusions; Bibliography.

RESUMO As atividades produtivas realizadas na bacia de Riogrande II (Antioquia, Colômbia) geram afetações ambientais negativas sobre o solo e a água. A integração de modelos hidrológicos e econômicos fornece uma base científica para um cenário planejado de uso do território que seja racional e adequado à agropecuária. A partir de dados gerados com o modelo SWAT, o modelo Ecosaut é reformulado para determinar o ótimo uso do solo de acordo com restrições ambientais e sociais; assim, verificou-se que, para garantir a sustentabilidade da bacia, é necessário implantar um sistema de rodízio de pastagem e de plantação de batata junto com uma redução de 42 % do solo atualmente dedicado a atividades agrícolas. JEL: Q12, Q15, Q24, Q25 CONTEÚDO: Introdução; 1. Caracterização da bacia; 2. Metodologia; 3. Resultados e discussão; 5. Conclusões; Bibliografia.